This week's Clone Zone classic game features the Sept. 4, 2004 Iowa State vs. Northern Iowa matchup from Jack Trice Stadium, a game ISU won 23-0. Iowa State showcased a stingy defense, allowing 2003 NCAA Division I-AA quarterfinalist Northern Iowa just 99 net yards, the lowest mark by an ISU opponent since Colorado State totalled 96 yards in 1980. Northern Iowa, 10-3 in 2003, did not cross the 50-yard line until reaching the Iowa State 49 late in the game. Senior LB Brandon Brown spearheaded the ISU defense, making eight tackles.

DE Tyson Smith made seven stops, while JUCO transfer LaMarcus Hicks added five tackles. Iowa State TB Stevie Hicks rushed for 111 yards on 23 carries, becoming the first Cyclone with back-to-back 100 yard games since Michael Wagner in 2002 (107 vs. Nebraska, 102 vs. Texas Tech).

Redshirt freshman QB Bret Meyer became the second ISU signal-caller in as many years to get the starting nod for the opener. Meyer completed 15-of-24 passes for 139 yards and a touchdown. Sophomore QB Austin Flynn was 2-of-3 with a touchdown pass. WR Todd Miller led the receiving corps with five catches for 51 yards. Jon Davis and Todd Blythe each picked up the first touchdown catches of their careers. Blythe's came from Flynn, and was also his first-ever catch as a Cyclone.

Iowa State outgained UNI 378-99 and led 17-0 at the half.