Tailback Hiawatha Rutland rushed for a career-high 122 yards on 20 carries with a score; QB Seneca Wallace threw for 234 yards, and the Iowa State defense held Kansas to 150 total yards in a 45-3 Cyclone victory over the Jayhawks. The 150 yards allowed by the ISU defense was the best Cyclone defensive performance against a conference foe since 1979.

Three interceptions led to Cyclone touchdowns and ISU's six rushing TDs were the most by an ISU offense against a league opponent since 1977. Iowa State led 3-0 when LB Jeremy Loyd picked off a Zach Dyer pass at the KU 27-yard line. Lane Danielsen scored on a 9-yard reverse four plays later. Rutland scored on a 7-yard run, while TB Michael Wagner scored on runs of one and six yards. Redshirt freshman Brian Thompson made his debut, rushing for 92 yards on 14 carries and two TDs, all in the fourth quarter.

Ellis Hobbs and Nick Linder each made their second career interceptions. LB Brandon Brown paced Iowa State with 11 tackles (seven solo) and one sack.